PARP1-Chromobody

Visualization of DNA damage

The PARP1-Chromobody® visualizes endogenous PARP1 in real time in live cells.

The PARP1-Chromobody comprises the anti-PARP1 VHH derived from alpaca heavy chain antibody genetically fused to TagRFP or TagGFP2.

Specificity
PARP1, human

Applications
Monitor recruitment of PARP1 to DNA damage in real time
Live cell imaging
PARP1 as biomarker of DNA damage after microirradiation

PARP1-Chromobody products
PARP1-Chromobody plasmids
PARP1-Chromobody cell line ->  Please inquire!

Benefits

  • Easily transfect your cells
  • Use PARP1-Chromobody® as marker of DNA damage after microirradiation
  • PARP1-Chromobody® does not affect cell viability

About PARP1

Poly (ADP-ribose) polymerase 1 (PARP1) is one of the most abundant proteins in the nucleus and is involved in many cellular processes like DNA repair, transcriptional regulation, and modulation of chromatin structure.

PARP1-Chromobody Plasmid (tagGFP)

Mammalian expression vector encoding PARP1-VHH fused to the green fluorescent protein TagGFP2 (Evrogen)

PARP1-Chromobody Plasmid (tagRFP)

Mammalian expression vector encoding PARP1-VHH fused to the red fluorescent protein TagRFP (Evrogen)

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Only for research applications, not for diagnostic or therapeutic use!