Histone-Chromobody

Trace chromatin in live cells non-invasively

The ChromoTek Histone-Chromobody®* is a novel probe to visualize chromatin dynamics in live cells.

The Histone-Chromobody consists of a camelid single-domain antibody (so-called VHH or Nanobody) fused to enhanced green fluorescent protein (EGFP).

Specificity
Histone H2A-H2B heterodimer; tested in yeast, flies, and mammalian cells

Applications
Live cell imaging

Histone-Chromobody products
Histone-Chromobody plasmid

Benefits

  • Easily transfect your cells with the Histone-Chromobody plasmid
  • Histone-Chromobody as marker of chromatin, nucleosomes, and histones
  • Histone-Chromobody does not intercalate in DNA
  • Histone-Chromobody is non-toxic for cells over extended periods of time (up to 3 days)

About histone H2A-H2B heterodimer

Two histones, H2A and H2B, interact to form the H2A-H2B heterodimer. Together with a H3-H4 tetramer, two H2A-H2B dimers form the histone octamer. The histone octamer is also called nucleosome core. DNA wraps around the nucleosome to form the nucleosome. Nucleosomes are packing units, which form eukaryotic chromatin. 

Histone-Chromobody Plasmid (EGFP)

Histone-Chromobody consists of an anti-histone H2A-H2B heterodimer VHH fused to EGFP.

*Commercialized under a license of INRA, the French National Institute for Agricultural Research

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Only for research applications, not for diagnostic or therapeutic use!