Monitor the nuclear morphology in live cells non-invasively
The Lamin-Chromobody® visualizes the nuclear lamina.
The Lamin-Chromobody consists of anti-Lamin VHH fused to a fluorescent protein. The Lamin-Chromobody enables you to observe nuclear morphology in real time in your cell line of interest. The Lamin-Chromobody can be used for High-Content Analysis (HCA).
Lamin A/C, tested in human cell lines (HeLa, U2OS) and insect S2 cells.
Visualize the nuclear lamina
Live cell imaging
Biosensor for real-time assays of mitosis or apoptosis
- Visualize the nuclear lamina without interfering with its cellular functions
- Monitor the nuclear integrity and morphology during live cell microscopy
- Stable fluorescent HeLa and U2OS cell lines ready to go for cellular screening
Lamin-Chromobody as biomarker
For simultaneous read out of
- Cell size and morphology
- Nuclear morphology
About nuclear lamina
The nuclear lamina is a meshwork enclosing the entire nucleus - the control center of eukaryotic cells. Its function is to hold together nuclear content and to add mechanical support to the nucleus. The nuclear lamina is a very sensitive subcellular structure. It has to maintain a certain rigidity and at the same time allow structural dynamics. Therefore, artificial incorporation of ectopically overexpressed fluorescently tagged lamins often leads to undesired cytotoxic side effects. The new Lamin-Chromobody binds to Lamin A/C and overcomes these unwanted side effects.
Lamin-Chromobody Plasmid (TagGFP2)
Only for research applications, not for diagnostic or therapeutic use!