Nanobodies / V_HHs

Unconjugated primary single-domain antibodies

VHHs, also termed Nanobodies, are derived from heavy chain only antibodies of Camelids. ChromoTek’s V_HHs are well characterized and validated. Because the molecular weight of these single-domain antibodies (sdAb) is just about 15 kDa, V_HHs are only one-tenth the size of a conventional IgG antibody (150 kDa) or less than a third the size of a Fab fragment (50 kDa).

Properties:

• Small size
• Single poly-peptide chain structure

Applications:

• Suitable for conjugation to dyes, biotin, beads, surfaces etc. via NHS ester reaction